Abstract—Plate-like AFI zeolite molecular sieves (SAPO-5) were synthesized and utilized for the fixed-bed separation of industrially important feedstock of xylenes isomers. The SAPO-5 crystal powders, which were synthesized using microwave heating technique together with seeds, present homogeneous porous structure (~0.73nm), particle size, as well as low aspect ratio. Adsorption experiments indicated that the sample present strong selectivity for o-xylene. Fixed bed separation of different xylene mixtures were measured experimentally and modeled using the Thomas model. It was found that the model can fit the kinetics of pure xylene and binary xylene mixtures reasonably well.